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A 6-year-old boy with fever and eosinophilia

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Tissue and blood eosinophilia can be associated with a variety of infectious, allergic, and systemic diseases. Eosinophilia can range from mild and clinically inconsequential levels to high-grade eosinophilia with severe and potentially fatal consequences. Because of its ability to degranulate and produce cytotoxic mediators such as major basic protein and eosinophil peroxidase the eosinophil has the potential to cause considerable tissue damage, including potentially fatal conditions such as endomyocardial fibrosis. The most common infectious cause of eosinophilia worldwide is the parasitic helminth; fungal infection as a cause of eosinophilia is rarer, but must also be considered in the differential diagnosis. In this article we describe a unique case of reactive eosinophilia.

Keywords: Amphotericin B; Candida parapsilosis; IL-5; IgE; caspofungin; eosinopenia; eosinophil; eosinophilia; fever; fungal infection

Document Type: Research Article

Affiliations: University of Texas Southwestern Medical Center, Dallas, Texas, USA. [email protected]

Publication date: November 1, 2009

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

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