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Free Content Comparative in vitro performance of valved holding chambers with a budesonide/formoterol pressurized metered-dose inhaler

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A combination of budesonide and formoterol in a single pressurized metered-dose inhaler (pMDI) is available in the United States and elsewhere. This study was designed to evaluate the delivered dose and fine particle dose (FPD; mass of particles <4.7-micrometer diameter) using the pMDI with two valved holding chambers (VHCs), using sampling methods reflecting different patient techniques. FPD was measured using an Andersen Cascade Impactor and delivered dose was measured using a disposable filter. Two VHCs, AeroChamber Plus and AeroChamber MAX (Trudell Medical International, London, Ontario, Canada), were evaluated using three sampling methods: (1) immediate collection; (2) collection after up to a 5-second delay; (3) using simulated adult, child, and infant tidal breathing patterns (delivered dose). Decreases in delivered dose were observed using a VHC compared with the pMDI alone. FPD with both VHCs was similar to that with the pMDI alone with minimal delay between actuation and collection. With delays, the antistatic AeroChamber MAX was more resistant than AeroChamber Plus to dose losses. Delivered doses from adult and child profiles were comparable with those after a 1-second delay. The infant profile produced lower delivered doses, probably because more breath cycles are required to empty the VHC. Budesonide/formoterol pMDI can be used effectively with AeroChamber Plus and the antistatic AeroChamber MAX. With minimal delay between actuation and collection, FPD with both VHCs was similar to that with the pMDI alone, giving physicians a choice of administration regimen and taking into account the needs and skills of the patient.

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Keywords: Asthma; budesonide/formoterol; corticosteroid; delivered dose; drug delivery; fine particle dose; long-acting beta2-adrenergic agonist; pressurized metered-dose inhaler; tidal breathing pattern; valved holding chamber

Document Type: Research Article

Publication date: July 1, 2009

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. AAP welcomes the submission of original works including peer-reviewed original research and clinical trial results. Additionally, as the official journal of the Eastern Allergy Conference (EAC), AAP will publish content from EAC poster sessions as well as review articles derived from EAC lectures.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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