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Eosinophilic gastrointestinal disorders

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Eosinophilic gastrointestinal disorders (EGID) are frequently encountered by the practicing allergist/immunologist. This is due to the occurrence of the disorders in atopic subjects and because research has indicated that atopy-related genes, inflammatory cells, and mediators play a role in the pathogenesis of the disorders. The role of the allergist/immunologist includes making the diagnosis by eliciting the symptoms in the history and defining the atopic phenotype of the subject with regard to food and environmental allergens, using skin testing and possibly patch tests. Obtaining a tissue diagnosis with an esophagogastroduodenoscopy is essential for the diagnosis and may direct treatment with topical steroids, diet, or novel therapeutic agents, e.g., anti—IL-5 monoclonal antibodies. The allergist/immunologist also contributes to the management and design of therapeutic interventions and the long-term follow-up of the patients. This is important because the EGID have a chronic course marked by resolutions and relapses. This review takes a practical approach to the identification and management of the EGID by the allergist/immunologist.
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Keywords: Anti-IL5; diet; environmental allergy; eosinophilic esophagitis; esophagogastroduodenoscopy (EGD); food allergy; patch test; reflux; skin test; topical steroids

Document Type: Research Article

Affiliations: Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Publication date: January 1, 2009

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. AAP welcomes the submission of original works including peer-reviewed original research and clinical trial results. Additionally, as the official journal of the Eastern Allergy Conference (EAC), AAP will publish content from EAC poster sessions as well as review articles derived from EAC lectures.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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