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EG2 expressed by eosinophils as a clinically useful indicator of asthma

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The monitoring of airway inflammation is mandatory for the improved control of bronchial asthma. We previously reported that intracellular EG2 levels of eosinophils, a marker of bronchial asthma increased in asthma patients. In this study, we hypothesized that eosinophil EG2+ expression increases during airway inflammation in asthmatic individuals. Eosinophil EG2+ and percentage eosinophil EG2+ with whole blood flow cytometry, eosinophil counts, serum total IgE, serum eosinophil cationic protein, eosinophil-derived neurotoxin, and percent of forced expiratory volume in 1 second/force vital capacity (FEV1/FVC) were measured in 33 asthmatic patients and 22 healthy volunteers. The relationships between these markers were evaluated. Comparisons were made on EG2+ expression between attack and asymptomatic periods in six asthmatic patients. EG2+ expression was significantly greater in the asthmatic patients than in healthy subjects. Furthermore, the EG2+ expression showed a significant increase during attacks. EG2+ expression inversely correlated with the FEV1/FVC. These results suggest that EG2+ expression may be a useful clinical marker of airway inflammation in asthma.
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Keywords: Allergy; ECP; FEV1/FVC; asthma; eosinophils; flow cytometry; marker EG2; whole blood

Document Type: Research Article

Affiliations: Central Clinical Laboratory, Akita University School of Medicine, Akita, Japan

Publication date: November 1, 2008

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. AAP welcomes the submission of original works including peer-reviewed original research and clinical trial results. Additionally, as the official journal of the Eastern Allergy Conference (EAC), AAP will publish content from EAC poster sessions as well as review articles derived from EAC lectures.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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