What lies beneath the surface of the itch in adults?
Pruritus is synonymous with itching. Many medical conditions are complicated by chronic pruritus compromising the patient's quality of life. The majority of pruritic stimuli are transmitted through C fibers into the lateral spinothalamic tract and then into the somatic sensory cortex where the itching is detected. Histamine, substance P, and tumor necrosis factor α play significant roles in the perception of pruritus. Medical conditions in adults with significant pruritus will be defined in this review.
Keywords: ADVERSE DRUG EFFECT; ATOPIC DERMATITIS; C FIBERS; HISTAMINE; INSECT BITE; PRURITUS; PSYCHIATRIC DISEASE; SUBSTANCE P; URTICARIA; XEROSIS
Document Type: Research Article
Affiliations: Allergy and Pulmonary Services, Scott & White Clinic, College Station, Texas, Department of Internal Medicine, Texas A & M University Health Sciences Center, College Station, Texas
Publication date: 01 March 2007
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