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Relationship of complete respiratory dysfunction: One linked airway. A selective clinical discussion

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There is increasing clinical, immunologic, and pathophysiological consensus that allergic rhinitis (AR) and asthma are different manifestations of a single condition: inflammation of the upper and lower airways characterized by nasal and bronchial hyperresponsiveness. Most patients with asthma have AR and asthma is present in a large percentage of patients with AR. Rhinitis is a major risk factor for asthma. Treating rhinitis in patients with AR and asthma improves not only the rhinitis but also the asthma. It is becoming clinically evident and studies have confirmed that improving the upper airway also helps the lower airway. There appears to be a connection between upper and lower airway dysfunction, suggesting one linked airway. There also seems to be a relationship between AR and asthma, suggesting that the two conditions are manifestations of one syndrome of complete respiratory dysfunction. The evidence is compelling but it is not completely established.
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Document Type: Research Article

Publication date: May 1, 2005

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. AAP welcomes the submission of original works including peer-reviewed original research and clinical trial results. Additionally, as the official journal of the Eastern Allergy Conference (EAC), AAP will publish content from EAC poster sessions as well as review articles derived from EAC lectures.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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