@article {Stokes:2005:1088-5412:103,
title = "Ragweed Skin Test Responsiveness Correlates with Specific Immunoglobulin E Levels",
journal = "Allergy and Asthma Proceedings",
parent_itemid = "infobike://ocean/aap",
publishercode ="ocean",
year = "2005",
volume = "26",
number = "2",
publication date ="2005-03-01T00:00:00",
pages = "103-107",
itemtype = "ARTICLE",
issn = "1088-5412",
eissn = "1539-6304",
url = "https://www.ingentaconnect.com/content/ocean/aap/2005/00000026/00000002/art00005",
author = "Stokes, Jeffrey and Kessler, Richard and Philip, George and Casale, Thomas B.",
abstract = "Evaluation for allergic rhinitis requires an objective measure of atopy. Serum eosinophils, total and specific immunoglobulin E (IgE), and skin testing have been used as this measure. The objective of our study was to examine the relationship between in vitro allergy tests and in vivo responsiveness. We compared eosinophil counts, total IgE, and the specific IgE radioallergosorbent test (RAST) measurements to end point skin test titrations with ragweed. Forty subjects 18 years of age with at least a 2-year history of moderate to severe ragweed-allergic rhinitis and a positive skin-prick test to ragweed participated in this study with 33 subjects having data for all measurements. End point skin tests were performed by intradermal injection of 0.03 mL of threefold dilutions of standardized short ragweed extract into the forearm. Ragweed-specific IgE was significantly correlated to end point wheal and erythema concentrations. The results were similar whether the end point wheal (r = 0.714; p in vitro ragweed-specific IgE levels, but these tests are not equivalent indicators of the degree of IgE-mediated sensitivity.",
}