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Antihistamines: Treatment Selection Criteria for Pediatric Seasonal Allergic Rhinitis

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Given the absolute numbers of children suffering from seasonal allergic rhinitis (SAR) and the fact that this number is rising, there is an unquestionable need for safe and effective treatments for the disease. The limited seriousness of the symptoms of SAR belies their true impact: the disease can have a profound effect on children's quality of life and impair learning performance. Furthermore, SAR has been linked to a number of comorbid conditions and forms part of the "allergic march" to more serious diseases such as asthma. Antihistamines are administered to relieve the symptoms of SAR, but they do not represent a homogeneous group. For example, older-generation antihistamines are associated with side effects such as impaired psychomotor performance. Newer-generation antihistamines must be evaluated individually based on their proven efficacy and safety so as to tailor treatment to each child's needs. Effective and safe treatment of SAR, with an antihistamine that does not cause sedation, should improve children's quality of life and could prevent the development of more serious conditions, thus reducing morbidity and possible future health care expenditure.
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Document Type: Review Article

Publication date: March 1, 2005

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. AAP welcomes the submission of original works including peer-reviewed original research and clinical trial results. Additionally, as the official journal of the Eastern Allergy Conference (EAC), AAP will publish content from EAC poster sessions as well as review articles derived from EAC lectures.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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