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Immunomodulation and Allergy

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A major function of the immune system is to protect the body from infection and the diseases caused by infectious agents. The immune system also provides protection against cancer cells, for once they arise, cancers can essentially behave as "foreign" cells capable of causing pathology. In contrast, allergy is a manifestation of the immune response to certain environmental cells or molecules that are usually neither a threat for infection nor cancer. Allergic reactions are generally an annoyance, even life-threatening. I will focus on type I allergy, characterized in part by induction of IgE antibody responses to allergens. It should be noted that not all IgE responses cause allergic symptoms. There is even evidence that IgE responses to tropical helminthic parasites offer a degree of immunity to reinfection. I have three objectives: (1) review T cell differentiation leading to the Th1/Th2 paradigm; (2) evaluate the increased prevalence of atopy, including asthma, as a consequence of a Th2-dominated immune system; (3) relate the high prevalence of asthma in inner city United States black children to the relatively recent migration of their ancestors from tropical regions of Africa, where genetically biased Th2-dependent IgE responses may be important in protection against high burdens of parasitic worms.
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Document Type: Research Article

Publication date: July 1, 2000

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. AAP welcomes the submission of original works including peer-reviewed original research and clinical trial results. Additionally, as the official journal of the Eastern Allergy Conference (EAC), AAP will publish content from EAC poster sessions as well as review articles derived from EAC lectures.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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