Importance of the First Meal on the Development of Cow's Milk Allergy and Intolerance
A cohort of 1749 newborns from the municipality of Odense born during 1985 in the University Hospital of Odense were followed prospectively for the development of cow's milk allergy (CMA)/cow's milk protein intolerance (CMI) during their first year. The diagnosis of CMA/CMI was based on elimination/open milk challenge procedures according to generally accepted criteria. Thirty nine infants (2.2%) developed CMA/CMI. Infants with CMA/CMI were fed cow's milk formula daily during the first month of life significantly more often than infants in the study population (p < .001). All 39 infants with CMA/CMI had ingested cow's milk formula (40–830 mL) neonatally, whereas none of the 210 neonates without supplements of cow's milk formula developed CMA/CMI (p < .05). Based on a positive skin-prick test (2+ or more) and/or specific serum IgE antibody to cow's milk (AL-RAST class 2 or more) 16 infants were classified as having CMA. In infants solely breast-fed for >1 month CMA was as frequent (1% [14/1414] as in cow's milk formula fed infant (0.6% [2/335]. In infants with CMI, a significant majority (3.9% [13/335] versus 0.7% [10/1414], p < .001) had been cow's milk formula fed during the first month. These data indicate an association between early cow's milk formula feeding and development of reproducible adverse reactions to cow's milk protein. Early neonatal intake of cow's milk protein is probably a condition of sensitization and later adverse reactions to cow's milk protein.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
Document Type: Research Article
Publication date: July 1, 1991
More about this publication?
- Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.
The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. AAP welcomes the submission of original works including peer-reviewed original research and clinical trial results. Additionally, as the official journal of the Eastern Allergy Conference (EAC), AAP will publish content from EAC poster sessions as well as review articles derived from EAC lectures.
Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.
Articles marked "F" offer free full text for personal noncommercial use only.
The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
- Editorial Board
- Information for Authors
- Submit a Paper
- Information for Advertisers
- Reprint Requests
- Ingenta Connect is not responsible for the content or availability of external websites