Skip to main content
padlock icon - secure page this page is secure

Human Nasal and Bronchial Epithelial Cells in Culture: An Overview of Their Characteristics and Function

Buy Article:

$36.50 + tax (Refund Policy)

Our studies have demonstrated it is possible to culture both human nasal and bronchial epithelial cells to confluency under similar conditions in vitro. These cells are similar morphologically, histologically, and functionally and resemble the cells in vivo. Studies of ciliary activity demonstrate that these cells react toward various agonist and antagonist agents in a similar manner as the cells reported in vivo and consequently will prove to be a valuable model for the evaluation of various therapeutic agents used in the management of infective lung diseases. Similarly studies on the effect of histamine have demonstrated that histamine probably does lead to an increase in bronchial epithelial permeability in vivo and that this effect is likely to be mediated via stimulation of H-1 receptors. Again this could be of clinical relevance when formulating appropriate therapy. The finding that human tracheal and nasal epithelial cells in culture are capable of synthesizing PGE2 could have important clinical implications because this compound is thought to be a putative epithelium-derived relaxing factor. Although this finding awaits confirmation, similar studies with bronchial epithelial cells in vitro would provide a useful tool for study of the function of the bronchial epithelium and its role in the pathogenesis of diseases such as asthma and chronic bronchitis.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Document Type: Research Article

Publication date: March 1, 1991

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. AAP welcomes the submission of original works including peer-reviewed original research and clinical trial results. Additionally, as the official journal of the Eastern Allergy Conference (EAC), AAP will publish content from EAC poster sessions as well as review articles derived from EAC lectures.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
  • Editorial Board
  • Information for Authors
  • Submit a Paper
  • Information for Advertisers
  • Reprint Requests
  • Commercial level: Permission to use content
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more