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The Pathology of Asthma: With Emphasis on the Role of the Eosinophil

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The pathology of asthma is characterized by mucus plugging of the bronchi and bronchioles, shedding of the respiratory epithelium with the formation of Creola bodies, denudation of the epithelium, the presence of necrotic eosinophilic material beneath the epithelium, a thickened basement membrane zone, bronchial smooth muscle hypertrophy, and goblet cell hyperplasia. In addition, pronounced tissue eosinophilia is present and Charcot-Leyden crystals may be present in sputum. Information linking the eosinophil to the pathophysiology of asthma is presented and the possibility that the eosinophil is a major effector of the inflammation associated with asthma is discussed.
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Document Type: Research Article

Publication date: September 1, 1986

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. AAP welcomes the submission of original works including peer-reviewed original research and clinical trial results. Additionally, as the official journal of the Eastern Allergy Conference (EAC), AAP will publish content from EAC poster sessions as well as review articles derived from EAC lectures.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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