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Methods of Studying Antihistamines

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A variety of ingenious methods have been devised to challenge and incite episodes of acute allergic rhinitis in susceptible individuals. These methods teach us much about basic mechanisms involved in the disease. There is some danger in using them for efficacy trials because antihistamines are only partially effective treatment for hay fever and the challenge administered could easily overcome the degree of protection. Additional studies may lead to a better understanding of the factors involved in challenges and hence, their usefulness in clinical testing.

The out-patient trial design is successful in demonstrating efficacy in 40 to 60 per cent of trials. The field trial is 70 to 90 percent accurate in its findings.

The clinical design of antihistamine trials has improved remarkably in the past 10 years. Because of the nature of the disadvantages discussed throughout this report, I would doubt that further improvements in design will occur in future years unless a substitute is found for subjective evaluations.
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Document Type: Research Article

Publication date: July 1, 1986

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. AAP welcomes the submission of original works including peer-reviewed original research and clinical trial results. Additionally, as the official journal of the Eastern Allergy Conference (EAC), AAP will publish content from EAC poster sessions as well as review articles derived from EAC lectures.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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