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Regulation of IgE Synthesis in Man

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It is clear that T cells play a role in the regulation of IgE synthesis. This is in part mediated via the secretion of IgE binding factors which home on the IgE B cells and deliver either enhancing signals prompting the B cell to differentiate into secreting more IgE antibody or suppressor signals which shut off antibody production. A balance between these two signals will determine the magnitude of the IgE antibody response. The presence of IgE suppressor factor in normal serum and the presence of IgE helper factors in serum and in supernatants of cell lines from individuals with high IgE will allow us to better understand the mechanism of IgE regulation and devise more rational strategies for treatment of allergic diseases. Initial encouraging clinical results have been obtained with administration of normal serum and suppression of IgE synthesis. With the advent of hybridoma techniques and DNA recombinant technology, one should be able to isolate these factors in sufficient quantity, and test them safely in clinical situations.
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Document Type: Research Article

Publication date: March 1, 1985

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. AAP welcomes the submission of original works including peer-reviewed original research and clinical trial results. Additionally, as the official journal of the Eastern Allergy Conference (EAC), AAP will publish content from EAC poster sessions as well as review articles derived from EAC lectures.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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