Abnormalities in the Histamine-Induced Suppressor Cell Network in Atopic Subjects
Antibody responses of the IgE isotype, like other immunoglobulin classes, are regulated by a finely-tuned network of complex positive and negative regulatory factors. This paper reviews studies concerning abnormalities of histamine-induced suppressor T cell activity in atopic subjects. In atopic subjects, there is a reduction in the generation of histamine-induced suppressor cell activity which positively correlates with decreased phenotypic expression of histamine-type 2 receptors on T lymphocytes. Nonatopic control subjects with systemic mastocytosis have normal functional and phenotypic data, suggesting that chronic in vivo activation by histamine of T cells from atopies does not explain the abnormal histamine-induced suppressor response. Proper functioning of the histamine-induced suppressor cell system involves obligatory interactions between lymphocytes and monocytes. Monocytes from atopic subjects produced significantly less prostaglandin E2 in response to exogenous histamine-induced suppressor factor. A new immunostimulatory drug, Fanetizole mesylate, partially corrects the abnormal histamine-induced suppressor response. Clinical application of this information may lead to new treatments of the atopic diathesis.
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Document Type: Research Article
Affiliations: Pulmonary Center, Evans Memorial Department of Clinical Research, Boston University School of Medicine, Boston, MA
Publication date: September 1, 1984
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