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Histamine H1 and H2 Receptors

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Histamine, one of the major mediators of immediate hypersensitivity (allergic) reactions, is capable of eliciting a variety of physiologic responses (Table 2) of major clinical importance. The mediation of histamine's actions occurs as a consequence of the generation of either cyclic GMP or cyclic AMP subsequent to the stimulation of specific H1 or H2 receptors, respectively. The development of specific histamine receptor agonists and antagonists (Table 1) and radioligand binding techniques should prove useful in the elucidation of the precise sequence of events following histamine receptor interactions. In addition, knowledge of histamine receptor subtypes and histamine-induced post-receptor events have proven beneficial in the development of treatment modalities for diseases such as anaphylaxis and the Zollinger-Ellison syndrome.
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Document Type: Research Article

Affiliations: Allergic Diseases Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205

Publication date: September 1, 1984

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. AAP welcomes the submission of original works including peer-reviewed original research and clinical trial results. Additionally, as the official journal of the Eastern Allergy Conference (EAC), AAP will publish content from EAC poster sessions as well as review articles derived from EAC lectures.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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