The Effects of Age and Circadian Rhythm on Theophylline Pharmacokinetics in Normal Subjects
Theophylline metabolism is influenced by a wide variety of biochemical, pathological and environmental factors. These include diet, smoking, other drugs and various disease states. We investigated the effect of advanced age on theophylline disposition. Theophylline clearance rate was
higher (43.97 vs 32.97 ml kg−1 hr−1, p<0.001) and the elimination half-life was shorter (6.98 vs 8.14 hr, p<0.02) in the geriatric versus young age group.
We also studied the influence of circadian rhythm on theophylline disposition. In normal male volunteers, age 20-25 yr, there is a significant decrease in the serum theophylline concentration and the area under the serum theophylline concentration-time curve (AUC) during the night. Pharmacokinetic rate constants cannot be considered a priori to be identical for theophylline throughout a 24-hour period.
We also studied the influence of circadian rhythm on theophylline disposition. In normal male volunteers, age 20-25 yr, there is a significant decrease in the serum theophylline concentration and the area under the serum theophylline concentration-time curve (AUC) during the night. Pharmacokinetic rate constants cannot be considered a priori to be identical for theophylline throughout a 24-hour period.
Document Type: Research Article
Affiliations: Department of Internal Medicine, Division of Allergy and Immunology, University of South Florida College of Medicine, James A. Haley Veterans Administration Hospital, Tampa, Florida
Publication date: 01 September 1983
- Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.
The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. AAP welcomes the submission of original works including peer-reviewed original research and clinical trial results. Additionally, as the official journal of the Eastern Allergy Conference (EAC), AAP will publish content from EAC poster sessions as well as review articles derived from EAC lectures.
Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.
Articles marked "F" offer free full text for personal noncommercial use only.
The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service. - Editorial Board
- Information for Authors
- Submit a Paper
- Information for Advertisers
- Reprint Requests
- Commercial level: Permission to use content
- www.JFoodAllergy.com
- Ingenta Connect is not responsible for the content or availability of external websites
Receive new issue alert- Access Key
- Free content
- Partial Free content
- New content
- Open access content
- Partial Open access content
- Subscribed content
- Partial Subscribed content
- Free trial content