Antihistamines and Decongestants in the Treatment of Chronic Rhinitis
Antihistamines and decongestants are most effective in chronic non-infectious rhinitides. Chronic rhinitic symptomology includes nasal congestion and pruritus, sneezing, rhinorrhea and "post-nasal" drip. Decongestants are typically thought to decrease congestion by stimulation of alpha
adrenergic receptors of the nasal mucosa, while antihistamines decrease the latter symptoms by preventing the mediator effects of released histamine.
Misuse of decongestants and detoxification are perplexing problems facing the clinician, as well as tolerance to antihistamine effect. Anticipation and avoidance of decongestant toxicity in patients with high blood pressure, cardiovascular disease, diabetes, thyroid disease as well as neurological and psychologic drug effects are discussed. Tabulation of currently used single antihistamine and decongestants as well as most commonly used combinations of both are also presented.
Misuse of decongestants and detoxification are perplexing problems facing the clinician, as well as tolerance to antihistamine effect. Anticipation and avoidance of decongestant toxicity in patients with high blood pressure, cardiovascular disease, diabetes, thyroid disease as well as neurological and psychologic drug effects are discussed. Tabulation of currently used single antihistamine and decongestants as well as most commonly used combinations of both are also presented.
Document Type: Research Article
Publication date: 01 September 1982
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