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The Effect of Inhaled Beclomethasone on Serum Immunoglobulins

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Oral and parenteral adrenal corticosteroids have a significant effect on serum immunoglobulins. This effect appears to be sensitive and causes primarily a decrease in serum immunoglobulin G (IgG) and a transient increase in serum immunoglobulin E (IgE). The purpose of this study is to determine if inhaled Beclomethasone causes similar changes in serum immunoglobulins.

Ten asthmatic patients (20% or greater reversibility in FEV1 after Isoproterenol) and 10 age and sex matched controls were studied. Asthmatic patients were placed on inhaled Beclomethasone (400 g/day in 4 divided doses) for at least 4 weeks. Blood was drawn on controls without Beclomethasone in a similar time sequence. Serum IgG decreased significantly (10.2% p ≤ 0.018. Wilcoxon matched-pairs signed-ranks test) in the post treatment sera of patients on Beclomethasone, while no significant change was found in the control sera (+1.0%). Eight of the ten asthmatics on Beclomethasone had a net decrease in IgG, one remained unchanged, and one had an increase of 4%. There was no significant change in other immunoglobulins. In summary, Beclomethasone administered in usual doses for 4 weeks appears to produce a significant decrease in serum IgG.
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Document Type: Research Article

Publication date: June 1, 1981

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. AAP welcomes the submission of original works including peer-reviewed original research and clinical trial results. Additionally, as the official journal of the Eastern Allergy Conference (EAC), AAP will publish content from EAC poster sessions as well as review articles derived from EAC lectures.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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