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Prostaglandins and Inflammation

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Prostaglandins and leukotrienes are derivatives of unsaturated fatty acids acting as mediators of inflammation. Inhibition of prostaglandin synthesis by nonsteroidal anti-inflammatory drugs accounts for their anti-inflammatory effects in rheumatoid synovium and other tissues, and inhibition of prostaglandin synthesis by glucocorticoids contributes to their anti-inflammatory effects. Endogenous polypeptide factors produced by peripheral blood monocytes, rheumatoid synovium and other tissues stimulate prostaglandin synthesis and may be important in inflammatory processes. Alterations in the fatty acid composition of the diet may lead to changes in production of prostaglandins and leukotrienes, and thereby may be expected to alter inflammatory responses.
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Document Type: Research Article

Publication date: 01 March 1981

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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