Arachidonic Acid Cascade: The Cyclooxygenase Pathway
Arachidonic acid present in cell membranes is enzymatically converted to prostaglandins of varying biologic activity, depending upon cell type, by the cyclooxygenase pathway. Prostacyclin (PGI2) synthesized by vascular endothelium, and thromboxane A2 (TXA2), synthesized by platelets, have opposing modulatory effects upon hemostasis and vascular tone. The balance between these prostaglandins is affected by plasma factors, availability of arachidonate as substrate, and rates of enzyme inactivation. Aspirin has profound effects upon prostaglandin synthesis by irreversibly acetylating the pivotal enzyme cyclooxygenase, leading to therapeutically useful changes in PGI2-TXA2 interactions.
Document Type: Research Article
Publication date: 01 March 1981
- Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.
The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. AAP welcomes the submission of original works including peer-reviewed original research and clinical trial results. Additionally, as the official journal of the Eastern Allergy Conference (EAC), AAP will publish content from EAC poster sessions as well as review articles derived from EAC lectures.
Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.
Articles marked "F" offer free full text for personal noncommercial use only.
The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service. - Editorial Board
- Information for Authors
- Submit a Paper
- Information for Advertisers
- Reprint Requests
- Commercial level: Permission to use content
- www.JFoodAllergy.com
- Ingenta Connect is not responsible for the content or availability of external websites
Receive new issue alert- Access Key
- Free content
- Partial Free content
- New content
- Open access content
- Partial Open access content
- Subscribed content
- Partial Subscribed content
- Free trial content