The Neural-Chemical Control of Breathing in Asthma
Current concepts of the control of breathing are briefly reviewed with emphasis on those aspects relevant to the asthmatic. Two control problems in the asthmatic are presented. One, the paradoxical presence of hyperventilation in most asthmatics during an acute attack is discussed in the context of the response of the respiratory control system to airway obstruction in various settings. Two, recent studies are reviewed which show that sleep-related disturbances in breathing occur in apparently normal humans and in patients with lung disease. The abnornalities observed in the few such studies in asthmatics, the possible significance of sleep-related breathing disturbances in the long term morbidity and mortality of patients with other types of lung disease, and the frequent occurrence of noctural asthma indicate that more careful and extensive evaluation of the control of breathing during sleep in asthmatics is necessary.
Document Type: Research Article
Publication date: 01 December 1981
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