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Synthesis and hplc monitoring of a new manganese complex with catalase and superoxide dismutase like activity.

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We have synthesized an unsymmetrical salen-manganese complex to test its catalytic properties and possibly its application in controlling some aspects of oxidative stress in vitro and in vivo models. The ligand used in this study was a Schiff base obtained by condensing o-vanillin with 1,2 diamino propane. Manganese forms a symmetrical and stable coordinative bridge at the center of the complex and cannot be released. In the medium where it could display its toxic effects. This complex is a new low-molecular-weight compound that exhibits good Catalase and Superoxide Dismutase activities, destroying both superoxide and hydrogen peroxide. All described reactions are important for cell detoxification and in a variety of consequences such as aging, cancer diabetes and vitiligo. Clinical applications of cat-like molecules is a primary target because the natural enzyme cannot be used as a drug due to its instability in solution and to delivery problems. Therefore, we were prompted to synthesize a compound presenting definite characteristics to be used as mimic enzyme in vivo : (1) non-toxic at required concentrations, (2) active within the physiological pH range, (3) high stability constant, (4) its metabolism and fate can be monitored in vivo (to study dose-effect correlation) For this purpose we have set-up a simple and fast chromatographic method to monitor synthesis and degradation of these compounds. This method can be used without modification also to test light and thermal stability of preparations (i.e. vitiligo treatment) and to monitor metabolism and fate in humans.
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Document Type: Research Article

Affiliations: 1: Clinical and Experimental Medicine, Perugia University, Perugia, Italy 2: via Brigata Lupi 3, Bergamo

Publication date: August 1, 2004

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