Skip to main content
padlock icon - secure page this page is secure

Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats

Buy Article:

$52.00 + tax (Refund Policy)


Melatonin reportedly exerts beneficial effects to attenuate multiple organ dysfunction syndrome (MODS) in septic shock. Heatstroke resembles septic shock in many aspects. Thus, this study was performed on the anesthetized rats by using heat exposure to induce heatstroke-associated MODS. We evaluated the effect of melatonin, a versatile molecule synthesized in the pineal gland and in many organs, in heatstroke rats and showed that melatonin (0.2–5.0 mg/kg of body weight, i.v., immediately after the start of heat stress) significantly (i) attenuated hyperthermia, hypotension and hypothalamic ischemia and hypoxia, (ii) reduced plasma index of the toxic oxidizing radicals like nitric oxide metabolites and hydroxyl radicals, (iii) diminished plasma index of hepatic and renal dysfunction like creatinine, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase, (iv) attenuated plasma systemic inflammation response molecules like soluble intercellular and lesion molecule-1, E-selectin, tumor necrosis factor-alpha, interleukin (IL)-1β, and IL-6, (v) promoted plasma levels of an anti-inflammatory cytokine IL-10, (vi) reduced an index of infiltration of polymorphonuclear neutrophils in the lung like myeloperoxidase activity, and (vii) promoted the survival time to fourfold compared with the heatstroke alone group. Thus, melatonin could be a novel agent for the treatment of heatstroke animals or patients in the early stage.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: free radicals; heatstroke; melatonin; multiple organ dysfunction syndrome; rat; septic shock

Document Type: Research Article

Affiliations: 1: Department of Critical Care Medicine, General Hospital Guangzhou Military, Guangzhou, China 2: Department of Pharmacy, Nanfang Hospital and Southern University, Guangzhou, hina 3: Department of Neurobiology, Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing, China 4: Rehabilitation Department of Spinal Cord Injury, General Hospital Jinan Military, Shandong, China

Publication date: May 1, 2011

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more