The modulation of neuronal activity by melatonin: In vitro studies on mouse hippocampal slices
The influence of melatonin on evoked potentials recorded from the CA1 field of mouse hippocampal slices was investigated. Melatonin (0.1–2.0 mM) and its analog, 6-chloromelatonin (0.1–0.5 mM) depressed evoked potentials (EPSP and the population spike) in a concentration-dependent manner. The melatonin-induced depression was followed by a slow recovery phase. Since the fiber potential was not affected, it was concluded that melatonin influenced synaptic efficiency and/or cell excitability. Luzindole, an antagonist of MT2 melatonin receptors, although slightly depressing evoked potentials when applied by itself (100 M), blocked any further inhibition by melatonin when added afterwards. We concluded that melatonin reduced synaptic efficiency and/or excitability of hippocampal neurons most likely through interaction with MT2 melatonin receptors, but other possible mechanisms of melatonin action are also considered.
No Supplementary Data
No Article Media
Document Type: Research Article
Affiliations: Department of Biology/CSI/IBR Center for Developmental Neuroscience, College of Staten Island/CUNY, 2800 Victory Boulevard, Staten Island, New York 10314, USA;
Publication date: March 1, 2001