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The effectiveness of systemic eradication therapy against oral Helicobacter pylori

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J Oral Pathol Med (2010) 40: 428–432 Background: 

Helicobacter pylori infection is associated with numerous gastroduodenal diseases. The oral cavity could be a potential extragastric reservoir for H. pylori, and oral H. pylori might cause gastric reinfection after the eradication therapy. The aim of the study was to evaluate the presence of H. pylori in oral cavity of patients with gastric H. pylori infection and to examine the effectiveness of the eradication therapy against H. pylori in stomach and in the oral cavity. Methods: 

Fifty-six patients with chronic periodontitis and gastric H. pylori were enrolled in the study. Gastric H. pylori infection was determined using 13C-urea breath test before and 3 months after eradication therapy. The presence of the oral H. pylori was assessed using polymerase chain reaction before and 3 months after eradication therapy. The 1-week eradication therapy consisted of amoxycilin 1 g, clarithromycin 500 mg, and proton pump inhibitor 20 mg twice a day. Results: 

Of 56 subjects with gastric infection, 23 (41.1%) harbored H. pylori in the oral cavity. Eradication rate in stomach was 78.3%, whereas in the oral cavity, H. pylori was not detected from any sample after the eradication therapy. Conclusion: 

Almost half of the patients with gastric H. pylori harbored the bacterium in the oral cavity. After the eradication therapy, H. pylori was not detected in the oral cavity, what suggests high effectiveness of the therapy protocol in the oral cavity, or it is possible that oral H. pylori is of a transient character.
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Keywords: Helicobacter pylori; oral cavity; reinfection

Document Type: Research Article

Affiliations: 1: Department of Endodontics and Restorative Dentistry, School of Dental Medicine, University of Zagreb, Zagreb, Croatia 2: Department of Gastroenterology and Hepatology, Internal Medicine Clinic, Clinical Hospital ‘Sveti Duh’, Zagreb, Croatia 3: Department of Microbiology, School of Medicine, University of Zagreb, Zagreb, Croatia 4: Department of Periodontology, School of Dental Medicine, University of Zagreb, Zagreb, Croatia

Publication date: May 1, 2011

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