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Cytochemical flow analysis of intracellular G6PD and aggregate analysis of mosaic G6PD expression

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Medicines that exert oxidative pressure on red blood cells (RBC) can cause severe hemolysis in patients with glucose‐6‐phosphate dehydrogenase (G6PD) deficiency. Due to X‐chromosome inactivation, females heterozygous for G6PD with 1 allele encoding a G6PD‐deficient protein and the other a normal protein produce 2 RBC populations each expressing exclusively 1 allele. The G6PD mosaic is not captured with routine G6PD tests.
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Keywords: G6PD deficiency; Plasmodium vivax; hemolytic anemia; lyonization; malaria

Document Type: Research Article

Publication date: March 1, 2018

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