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Reduced DNA methylation and hydroxymethylation in patients with systemic mastocytosis

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As disruption of epigenetic control is a frequent event in solid tumors and leukemia, we investigated changes in DNA methylation (5mC) and hydroxymethylation (5hmC) in patients with systemic mastocytosis (SM), a rare myeloproliferative disease with a wide spectrum of severity, characterized by the accumulation of mast cells in various organs.
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Keywords: 5‐hydroxymethylation; DNA methylation; TET2; epigenetics; systemic mastocytosis

Document Type: Research Article

Publication date: December 1, 2015

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