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Complex MLL rearrangement in non‐infiltrated bone marrow in an infant with stage II precursor B‐lymphoblastic lymphoma

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Precursor B‐lymphoblastic lymphoma cells are indistinguishable by morphology, and immune phenotype from lymphoblasts in acute leukemia which in infancy is associated with MLL rearrangements and a poor prognosis. The role of MLL gene deregulation in rare cases of isolated lymphoblastic lymphoma in infants is obscure. We report the case of a 10‐month‐old child who presented with a cutaneous nodule on the left foot. Histological diagnosis was precursor B‐lymphoblastic lymphoma. The young age of the patient motivated us to investigate the presence of an MLL rearrangement.
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Keywords: B‐lymphoblastic lymphoma; MLL rearrangement; infant ALL

Document Type: Research Article

Publication date: October 1, 2014

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