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Circulating KIT D816V mutation‐positive non‐mast cells in peripheral blood are characteristic of indolent systemic mastocytosis

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Abstract

It is presently accepted that the KIT D816V mutation is detectable in tissues with neoplastic mast cells in most patients with indolent systemic mastocytosis. In this study, neoplastic mast cells were detected in bone marrow, but not in peripheral blood, by flow cytometry in all 25 included cases of indolent systemic mastocytosis. However, the KIT D816V mutation was detected using mutation‐specific qPCR in both bone marrow and peripheral blood in all 25 cases, demonstrating for the first time that the KIT D816V mutation is consistently present in non‐mast cells in indolent systemic mastocytosis and that these cells are circulating in peripheral blood.
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Document Type: Research Article

Publication date: July 1, 2012

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