@article {Capovilla:2008:0902-4441:81,
title = "Synchronous FIP1L1PDGFRA-positive chronic eosinophilic leukemia and T-cell lymphoblastic lymphoma: a bilineal clonal malignancy",
journal = "European Journal of Haematology",
parent_itemid = "infobike://mksg/ejh",
publishercode ="bp",
year = "2008",
volume = "80",
number = "1",
publication date ="2008-01-01T00:00:00",
pages = "81-86",
itemtype = "ARTICLE",
issn = "0902-4441",
eissn = "1600-0609",
url = "https://www.ingentaconnect.com/content/mksg/ejh/2008/00000080/00000001/art00012",
doi = "doi:10.1111/j.1600-0609.2007.00973.x",
keyword = "T-cell lymphoblastic lymphoma, CHIC2 deletion, FIP1L1−PDGFRA rearrangement, hypereosinophilia, chronic eosinophilic leukemia",
author = "Capovilla, Mathieu and Cayuela, Jean-Michel and Bilhou-Nabera, Chryst{\‘e}le and Gardin, Claude and Letestu, Remi and Baran-Marzak, Fanny and Fenaux, Pierre and Martin, Antoine",
abstract = "Abstract Several reports of successful empirical treatment of idiopathic hypereosinophilic syndrome with imatinib led to the recent identification of the FIP1L1PDGFRA fusion gene rearrangement, which characterizes a distinctive group of chronic eosinophilic leukemias. This fusion gene can be detected in eosinophils, neutrophils, mast cells, T cells, B cells and monocytes in FIP1L1PDGFRA-positive hypereosinophilic patients suggesting a multilineage involvement. Furthermore, the same FIP1L1PDGFRA rearrangement was identified in patients with hypereosinophilia and atypical mast cell proliferations, raising the question of a disease with two concomitant lines of differentiation. In addition, a recent report noted two cases with the association of FIP1L1PDGFRA-positive chronic eosinophilic leukemia and T-cell lymphoblastic lymphoma (T-LBL). We report here the only third case of synchronous chronic eosinophilic leukemia and T-LBL, both associated with a FIP1L1PDGFRA fusion transcript, confirming the occurrence of such disease and suggesting a clonal proliferation with two lines of differentiation probably arising from a primitive multipotent medullary stem cell.",
}