Skip to main content
padlock icon - secure page this page is secure

Plasma cell growth fraction using Ki-67 antigen expression identifies a subgroup of multiple myeloma patients displaying short survival within the ISS stage I

Buy Article:

$52.00 + tax (Refund Policy)

Abstract

The current most powerful prognostic model in Multiple Myeloma (MM) combines beta-2 microglobulin (b2m) with albumin, corresponding to the International Staging System (ISS). However, the prognosis of patients within the ISS stage I (high albumin and low b2m) may vary. Ki-67 is a nuclear protein associated with cell proliferation. We retrospectively evaluated the percentage of bone marrow plasma cells expressing Ki-67 antigen (Ki-67 index) in a series of 174 untreated MM patients at diagnosis. Median survival was 51, 41 and 20 months respectively, and median Ki-67 index was 3.0%, 6.1% and 6.5% in ISS stages I, II, and III respectively. Independently of ISS, Ki-67 index ≥4% was highly predictive of adverse prognosis. Ki-67 index correlated with markers of intrinsic malignancy and with markers of tumour burden. Within ISS stage I, median survival was of 31 months (RR of death 2.65) in patients with Ki-67 index ≥4%. Eventually, the combination of Ki-67 with b2m produced an efficient prognostic model, which appeared most effective in our series when compared with b2m and KI-67 with chromosome 13 deletion models. In this series, we demonstrated that a proliferation marker provides clear-cut additional survival prognostic information to b2m into the ISS model.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: International Staging System; Ki-67; multiple myeloma; prognostic factor; proliferation index

Document Type: Research Article

Affiliations: 1: Service de Biostatistiques, CHRU, Lille 2: Laboratoire d’Hematologie and UPRES EA-3863 ‘analyse des déterminants de la réponse immunitaire’, CHU, Angers 3: Service de Genetique Medicale, CHRU, Lille, France 4: Service des Maladies du Sang, CHRU, Lille 5: Service d’Hématologie Clinique, CHU, Nantes, France

Publication date: October 1, 2007

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more