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Abnormality of CD4+CD25+ regulatory T cells in idiopathic thrombocytopenic purpura

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Abstract

Objectives: The aim of this study was to explore the profile and function of CD4+CD25+ regulatory T cells (Treg cells) in idiopathic thrombocytopenic purpura (ITP) patients. Methods: Treg cell numbers were analyzed by flow cytometric analysis in peripheral blood mononuclear cells collected from healthy donors or patients with ITP. Quantification of cell proliferation was assayed by an enzyme-linked immunosorbent assay kit, based on the measurement of BrdU incorporation during DNA synthesis. Results: The percentage of Treg cells was significantly decreased in ITP patients in active and non-remission state(5.79 ± 1.22%) when compared with the patients in remission(11.63 ± 4.56%) and to healthy subjects(12.68 ± 3.59%). The suppressive activity of Treg cells in ITP patients was also found to be impaired. Conclusion: These results suggest that decreased number and function of Treg cells might be one of mechanisms that cause immune regulation dysfunction in ITP.
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Keywords: idiopathic thrombocytopenic purpura; immunosuppression; regulatory T cells

Document Type: Research Article

Affiliations: 1: Division of Hematology and Hematologic Malignancies, Department of Medicine, University of Calgary, Calgary, AB, Canada 2: State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Publication date: February 1, 2007

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