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Resistant pure red cell aplasia after allogeneic bone marrow transplantation with major ABO mismatch treated by purified CD34+ cell infusion

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Woo H-Y, Min C-K, Lee S-M, Cho H-S, Kim S-Y, Lee S, Lee J-W, Min W-S, Kim C-C, Kim Y. Resistant pure red cell aplasia after allogeneic bone marrow transplantation with major ABO mismatch treated by purified CD34+ cell infusion.
Eur J Haematol 2005 © Blackwell Munksgaard 2005. Abstract: 

We report a case of pure red cell aplasia (PRCA) subsequent to an allogeneic bone marrow transplantation with a major ABO mismatch, which was resistant to the standard treatment options such as plasma exchange, erythropoietin and changes in the immunosuppressive treatment. Accordingly, two cycles of Rituximab therapy were administered without success. The patient had a chronic graft-vs.-host disease of the liver, which meant that an additional donor leukocyte infusion could not be introduced. Instead, purified CD34+ cells were administered after fludarabine and antithymocyte globulin therapy. As a result, the PRCA was resolved and the antidonor isohemagglutinin titer became undetectable.
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Keywords: ABO mismatch; CD34 cells; bone marrow transplantation; graft-vs.-host disease; pure red cell aplasia

Document Type: Research Article

Affiliations: 1: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 2: Department of Clinical Pathology, St Mary's Hospital, Seoul, Korea

Publication date: February 1, 2006

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