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Apoptosis and expression of anti- and pro-apoptotic proteins in peripheral blood mononuclear cells of Fanconi anaemia patients: a study of 73 cases

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Baruque GA, Bitencourt MA, Pasquini R, Castelo-Branco MTL, Llerena Jr JC, Rumjanek VM. Apoptosis and expression of anti- and pro-apoptotic proteins in peripheral blood mononuclear cells of Fanconi anaemia patients: a study of 73 cases.

Eur J Haematol 2005: 75: 384–390. © Blackwell Munksgaard 2005. Abstract: 

Fanconi anaemia (FA) is a rare genetic disease whose patients have a high predisposition to haematological abnormalities and cancer. Fas expression levels in peripheral blood lymphocytes samples of 73 FA patients were measured to verify if alterations in Fas expression could lead to predisposition/resistance to spontaneous or PHA induced apoptosis, as well as, to reflect some haematological features of this disease. The anti- and pro-apoptotic proteins Bcl-2 and Bax were also evaluated. FA patients samples could be divided into three different groups based on Fas expression: 20 samples had low, 32 normal and 21 increased Fas levels when compared to 41 control samples. No correlation was found between Fas and Bcl-2 expression but a good association was obtained with Bax, in the subgroup with increased Fas expression. The best correlation was seen between Bax expression and apoptosis. Out of the 15 samples with high Bax expression, 11 underwent apoptosis whereas only one out of seven samples with low levels of Bax displayed increased induced apoptosis. Most patients with normal haematological features expressed Fas within normal levels. It is difficult to establish, however, if Fas-expression is involved in the cause or is a consequence of the effects observed.
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Keywords: Bax; Fanconi anaemia; Fas receptor; apoptosis; flow cytometry; lymphocytes

Document Type: Research Article

Affiliations: 1: Serviço de Transplante de Medula Óssea/Hospital de Clínicas – UFPR, Brazil 2: Departamento de Histologia e Embriologia/ICB-CCS/UFRJ, Brazil 3: Instituto de Bioquímica Médica/CCS – UFRJ, Brazil

Publication date: November 1, 2005

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