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A case of post-transplant lymphoproliferative disease presenting as CD20-expressing, Epstein–Barr-virus positive Hodgkin lymphoma

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Stern M, Herrmann R, Rochlitz C, Dirnhofer S, Pless M. A case of post-transplant lymphoproliferative disease presenting as CD20-expressing, Epstein–Barr-virus positive Hodgkin lymphoma.

Eur J Haematol 2005: 74: 267–270. © Blackwell Munksgaard 2005. Abstract: 

Classical Hodgkin lymphoma (HL) is a rare complication after solid organ transplantation. We describe the first case of a patient developing CD20-positive HL after renal transplantation treated with the monoclonal antibody rituximab. Treatment with single agent rituximab led to partial remission. Subsequent combined modality treatment consisting of chemotherapy (adriamycin, bleomycin, vindesin and dacarbacin), immunotherapy (rituximab) and involved field irradiation achieved complete remission. Different therapeutic strategies in the treatment of patients developing lymphoproliferative disease – and particularly HL – after solid organ transplantation are discussed.
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Keywords: CD20; Epstein–Barr virus; Hodgkin lymphoma; post-transplant lymphoproliferative disease; rituximab

Document Type: Research Article

Affiliations: 1: Department of Hematology 2: Department of Medical Oncology, 3: Institute of Pathology, University Hospital Basel, Basel, Switzerland

Publication date: March 1, 2005

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