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Paroxysmal cold haemoglobinuria as a tardive complication of idiopathic myelofibrosis

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Breccia M, D'Elia GM, Girelli G, Vaglio S, Gentilini F, Chiara S, Alimena G. Paroxysmal cold haemoglobinuria as a tardive complication of idiopathic myelofibrosis.

Eur J Haematol 2004: 73: 304–306. © Blackwell Munksgaard 2004. Abstract: 

Paroxysmal cold haemoglobinuria (PCH) is an autoimmune haemolytic anaemia caused by the Donath–Landsteiner antibody. It is classically described in association with chronic syphilis or after acute viral infections. We describe the first case of PCH presented as a late manifestation of advanced myelofibrosis associated with antiphospholipid syndrome, that promptly responded to high dosage of prednisone.
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Keywords: Donath–Landsteiner antibody; myelofibrosis; paroxysmal cold haemoglobinuria

Document Type: Research Article

Publication date: October 1, 2004

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