Skip to main content
padlock icon - secure page this page is secure

A sustained response to low dose interferon-α in a case of refractory pure red cell aplasia

Buy Article:

$52.00 + tax (Refund Policy)

Nadeau L, Meyerson H, Warren G, Koç ON. A sustained response to low dose interferon-α in a case of refractory pure red cell aplasia.

Eur J Haematol 2004: 73: 300–303. © Blackwell Munksgard 2004. Abstract: 

Acquired pure red cell aplasia (PRCA) may be the result of a cellular or humoral autoimmune process. One proposed mechanism is the destruction of erythroid progenitors by self-reactive, cytotoxic T cells or natural killer (NK) cells. These cells normally express MHC class I receptors (KIR) which inhibit cytotoxicity when the target cell expresses the HLA class I antigen(s) they bind. Therefore, loss of these antigens on maturing erythroid progenitors may render them susceptible to destruction by the pathogenic cells. Interferon-α (INF-α) increases HLA class I expression on hematopoietic precursor cells. Therefore, we initiated a trial of INF-α in a patient with refractory PRCA. Following treatment, he developed transfusion independence, and a sustained normal hematocrit. Analysis of bone marrow erythroid cells revealed an increase in expression of HLA class I molecules. INF-α should be used in a controlled trial in patients with PRCA to determine its activity and mechanism of action.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: PRCA; red cell aplasia; refractory anemia

Document Type: Research Article

Publication date: October 1, 2004

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more