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Secondary follicular lymphoma of the bone, transformed into large cell lymphoma, in a patient with chronic lymphocytic leukaemia: an uncommon manifestation of Richter's syndrome

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Hensel M, Buss EC, Tiemann M, Parwaresch R, Libicher M, Fruehauf S, Ho AD. Secondary follicular lymphoma of the bone, transformed into large cell lymphoma, in a patient with chronic lymphocytic leukaemia: an uncommon manifestation of Richter's syndrome.

Eur J Haematol 2004: 72: 217–221. © Blackwell Munksgaard 2004. Abstract:

Patients with chronic lymphocytic leukemia (CLL) are at a significantly increased risk of developing a second malignant neoplasm in the course of their disease. The occurrence of large cell lymphoma [Richter's syndrome (RS)] has been described in approximately 3–5% of CLL patients. Other types of secondary lymphoid malignancies are extremely rare. Here we describe a patient, heavily pretreated, with long history of CLL who developed a secondary follicular lymphoma, transformed into a diffuse large cell lymphoma (LCL), with isolated manifestation in the bone, a very rare manifestation of RS. CLL and LCL cells were of distinct clonal origin, as documented by DNA sequencing of the CDR3 regions. Twelve months after the completion of chemo- and local radiotherapy, the patient is still in remission.
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Keywords: CCC; Richter's syndrome; follicular; large cell lymphoma; lymphoma; transformation

Document Type: Research Article

Affiliations: 1: Internal Medicine V 2: Department of Hematopathology, University of Kiel, Kiel, Germany 3: Radiology, University of Heidelberg, Heidelberg, Germany

Publication date: March 1, 2004

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