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Post-transfusion purpura (PTP) and disseminated intravascular coagulation (DIC)

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Welling K-L, Taaning E, Lund BV, Rosenkvist J, Heslet L. Post-transfusion purpura (PTP) and disseminated intravascular coagulation (DIC). Eur J Haematol 2003: 71: 68–71. © Blackwell Munksgaard 2003. Abstract:

A 47-yr-old female with acute pancreatitis received four units of fresh frozen plasma because of subtle signs of disseminated intravascular coagulation (DIC). Seven days later, she developed severe thrombocytopenia. Serological studies demonstrated antibodies against HPA-1a together with pan-reactive antibodies against platelet glycoproteins (GPIIb-IIIa, GPIb-IX and GPIa-IIa), which was consistent with the diagnosis of PTP. The patient was treated with platelet transfusions, corticosteroids and intravenous immunoglobulin (IVIG) without permanent beneficial effect. After treatment with plasma exchange the platelet count increased to normal values.
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Keywords: DIC; HPA-1a (Zwa) antibodies; pan-reactive platelet antibodies; plasma exchange; platelet alloimmunisation; post-transfusion purpura; thrombocytopenia; transfusion reaction

Document Type: Research Article

Affiliations: 1: Department of Intensive Care, 2: Department of Clinical Immunology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark 3: Department of Clinical Immunology, Rigshospitalet,

Publication date: July 1, 2003

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