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Pseudothrombocytopenia: a report of a new method to count platelets in a patient with EDTA- and temperature-independent antibodies of the IgM type

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van der Meer W, Allebes W, Simon A, van Berkel Y, de Keijzer MH. Pseudothrombocytopenia: a report of a new method to count platelets in a patient with EDTA- and temperature-independent antibodies of the IgM type.

Eur J Haematol 2002: 69: 243–247. © Blackwell Munksgaard 2002. Abstract:

Pseudothrombocytopenia is usually associated with blood specimens anticoagulated with ethylenediamine tetraacetic acid (EDTA) or other anticoagulants. It may be caused by temperature-independent, EDTA-dependent antibodies of the immunoglobulin-M (IgM) type. Here a patient with EDTA-independent and temperature-independent pseudothrombocytopenia mediated by IgM or IgM-containing immune complex is reported, and a reliable method is described for a proper counting of platelets in such cases.
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Keywords: EDTA; IgM; pseudothrombocytopenia

Document Type: Research Article

Affiliations: 1: Department of Clinical Chemistry, 2: Department of Blood Transfusion and Transplantation Immunology, and 3: Department of General Internal Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands

Publication date: October 1, 2002

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