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The prognostic significance of CA 125 in patients with non-Hodgkin's lymphoma

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Zacharos ID, Efstathiou SP, Petreli E, Georgiou G, Tsioulos DI, Mastorantonakis SE, Christakopoulou I, Roussou PP. The prognostic significance of CA 125 in patients with non-Hodgkin's lymphoma.

Eur J Haematol 2002: 69: 221–226. © Blackwell Munksgaard 2002. Abstract:

Objective: To assess the association of serum CA 125 in patients with non-Hodgkin's lymphoma (NHL) with prognostic parameters of the disease, response to treatment, and survival. Patients and methods: Sixty-eight patients [38 males, median age 56 (range 17–82) yr] with NHL were evaluated. CA 125 was measured by an enzyme immunoradiometric assay at diagnosis and at the end of first-line treatment. Results: Median overall CA 125 was 49 (1–963) U mL−1, whereas 49 patients had initially abnormal (>35 U mL) CA 125 levels. High CA 125 was found to correlate with failure of treatment (P = 0.001) and relapse (P = 0.01), and to be independently associated with bulky disease, effusions, LDH, and the International Prognostic Index (IPI) score (P<0.01 for each of these four variables). An initially abnormal CA 125 value was associated with poorer 5-yr survival [median survival of patients with CA 125>35 U mL−1 33 (18–72) months compared to 58 (20–77) months for those with CA 125 = 35 U mL−1, P = 0.012]. Moreover, CA 125>35 U mL−1 (among stage III/IV and LDH>460 mU mL−1) emerged as an independent predictor of death within 5 yr from diagnosis (Relative Risk (RR) 3.1, 95% CI 1.5–12.8, P = 0.02). Conclusion: Measurement of serum CA 125 is useful for staging, monitoring, and estimating prognosis in patients with NHL.
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Keywords: CA 125; non-Hodgkin's lymphoma; prognosis; survival; tumor marker

Document Type: Research Article

Affiliations: 1: Third University Department of Medicine, Sotiria Hospital, Athens, Greece; 2: Department of Nuclear Medicine, University of Athens, Medical School, Sotiria Hospital, Athens, Greece

Publication date: October 1, 2002

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