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Paraneoplastic cerebellar degeneration and nephrotic syndrome preceding Hodgkin's disease: case report and review of the literature

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Spyridonidis A, Fischer KG, Glocker FX, Fetscher S, Klisch J, Behringer D. Paraneoplastic cerebellar degeneration and nephrotic syndrome preceding Hodgkin's disease: case report and review of the literature.

Eur J Haematol 2002: 68: 318–321. © Blackwell Munksgaard 2002. Abstract:

A patient presented with symptoms of cerebellar degeneration and nephrotic syndrome. A work-up at that time failed to reveal an underlying disease; however, 20 months later Hodgkin's disease was diagnosed. Hodgkin's lymphadenopathy developed 2 wk after prednisone therapy for the nephrotic syndrome had been discontinued. Systemic polychemotherapy resulted in complete remission of both Hodgkin's disease and nephrotic syndrome, while the neurological deficit persisted. Patients with unexplained cerebellar degeneration and/or nephrotic syndrome demand extensive evaluation for the presence of Hodgkin's disease, and steroid therapy may delay diagnosis.
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Keywords: Hodgkin's disease; cerebellar degeneration; nephrotic syndrome

Document Type: Research Article

Affiliations: 1: Department of Hematology/Oncology; 2: Department of Nephrology; 3: Department of Neurology, University Medical Center, Freiburg; 4: Städtisches Krankenhaus Süd, Abt. Hämatologie/Onkologie, Lübeck; 5: Section of Neuroradiology, University Medical Center, Freiburg, Germany

Publication date: May 1, 2002

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