Paraneoplastic cerebellar degeneration and nephrotic syndrome preceding Hodgkin's disease: case report and review of the literature
Eur J Haematol 2002: 68: 318–321. © Blackwell Munksgaard 2002. Abstract:
A patient presented with symptoms of cerebellar degeneration and nephrotic syndrome. A work-up at that time failed to reveal an underlying disease; however, 20 months later Hodgkin's disease was diagnosed. Hodgkin's lymphadenopathy developed 2 wk after prednisone therapy for the nephrotic syndrome had been discontinued. Systemic polychemotherapy resulted in complete remission of both Hodgkin's disease and nephrotic syndrome, while the neurological deficit persisted. Patients with unexplained cerebellar degeneration and/or nephrotic syndrome demand extensive evaluation for the presence of Hodgkin's disease, and steroid therapy may delay diagnosis.
Document Type: Research Article
Affiliations: 1: Department of Hematology/Oncology; 2: Department of Nephrology; 3: Department of Neurology, University Medical Center, Freiburg; 4: Städtisches Krankenhaus Süd, Abt. Hämatologie/Onkologie, Lübeck; 5: Section of Neuroradiology, University Medical Center, Freiburg, Germany
Publication date: May 1, 2002