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Pulmonary embolism associated with tranexamic acid in severe acquired haemophilia

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Taparia M, Cordingley FT, Leahy MF. Pulmonary embolism associated with tranexamic acid in severe acquired haemophilia.

Eur J Haematol 2002: 68: 307–309. © Blackwell Munksgaard 2002. Abstract:

Tranexamic acid (an antifibrinolytic agent) is of proven benefit in the treatment of bleeding in patients with congenital and acquired coagulation disorders. We report the case of a patient with an acquired Factor VIII inhibitor, who was on a prophylactic dose of tranexamic acid because of recurrent bleeding episodes and developed a pulmonary embolism. Although studies using tranexamic acid have not shown a definite increased risk for the development of venous thrombosis, this is the likely cause of the pulmonary embolism in this patient.
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Keywords: Factor VIII inhibitor; thromboembolism; tranexamic acid

Document Type: Research Article

Affiliations: Department of Haematology, Fremantle Hospital, Western Australia, Australia

Publication date: May 1, 2002

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