Skip to main content
padlock icon - secure page this page is secure

Acute tumour lysis syndrome following a single-dose corticosteroid in children with acute lymphoblastic leukaemia

Buy Article:

$47.00 + tax (Refund Policy)

Abstract: Acute tumour lysis syndrome (ATLS) is a well recognised complication of treatment of a variety of malignant disorders. It commonly occurs in patients with non-Hodgkin's lymphoma (NHL) and acute lymphoblastic leukaemia (ALL) with the administration of combined cytotoxic chemotherapy. It is rarely reported after single-agent corticosteroid therapy. We present two children with acute lymphoblastic leukaemia of T-cell lineage who developed acute tumour lysis syndrome after a single dose of prednisolone, and methylprednisolone at the beginning of the induction chemotherapy. In the first case (an 11-yr-old) ATLS had occurred after an oral dose of prednisolone as small as 12 mg and within 18 h. The second case was a 14-yr-old boy with ALL who developed ATLS following a single dose of methylprednisolone. A few similar cases in the English literature are summarised in the report. These cases indicate that acute tumour lysis syndrome may occur after a single dose of corticosteroids. One should be aware of this potentially life-threatening complication especially while prescribing corticosteroids to patients with NHL and leukaemia.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: acute lymphoblastic leukaemia; methylprednisolone; prednisolone; tumour lysis

Document Type: Research Article

Affiliations: 1: Department of Pediatrics, Pediatric Nephrology and Rheumatology Unit, and 2: Department of Pediatrics, Pediatric Hematology Unit, Hacettepe University Faculty of Medicine, Ankara, Turkey

Publication date: June 1, 2001

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more