Immunomodulatory effects of moxifloxacin in comparison to ciprofloxacin and G-CSF in a murine model of cyclophosphamide-induced leukopenia
In normal mice the highest levels of GM-CSF and IL-6 were observed in lung-conditioned medium (compared to bone shaft, spleen and bladder). Injection of CP resulted in a 22.5- and 93-fold decrease in GM-CSF and IL-6 levels, respectively, in lung-conditioned medium, while treatment with quinolones resulted in 2–4-fold increase in GM-CSF with no effect on IL-6 production. G-CSF treatment had no enhancing effect on GM-CSF nor on IL-6 production. We conclude that moxifloxacin and ciprofloxacin administered to CP-injected mice revert some of the immune suppressive effects of cyclophosphamide.
Document Type: Research Article
Affiliations: 1: Schneider Children's Medical Center of Israel and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, 2: Department of Cell Biology and Histology, Sackler School of Medicine, Tel-Aviv, 3: University, Tel Aviv, Schneider Children's Medical Center of Israel, Petach-Tikva, and 4: Department of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel
Publication date: May 1, 2001