Skip to main content
padlock icon - secure page this page is secure

Treatment of T-prolymphocytic leukemia with nonmyeloablative allogeneic stem cell transplantation

Buy Article:

The full text article is temporarily unavailable.

We apologise for the inconvenience. Please try again later.

Abstract: Aim: T-prolymphocytic leukemia (T-PLL) is a rare disease of the elderly characterized by a high white blood cell count and organomegaly, and is currently incurable. Our aim was to elicit graft-versus-leukemia reactions in a patient with T-PLL. Methods: A 52-yr-old woman with refractory T-PLL underwent a nonmyeloablative regimen followed by allogeneic peripheral blood stem cell transplantation (a “minitransplant”) from her HLA-matched sibling. Results: There was no treatment related toxicity other than neutropenia. Engraftment was successful. The patient experienced no graft-versus-host disease (GVHD) at any time but, on day 84 after transplantation, had a relapse in the central nervous system. Despite infusion of donor lymphocytes and intralumbar chemotherapy, she died on day 157 of systemic disease. Conclusion: The reasons why treatment may have failed are discussed (nature of disease, disease progression, treatment schedule).

No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: T-prolymphocytic leukemia; leukemic meningitis; nonmyeloablative allogeneic transplantation

Document Type: Case Report

Affiliations: 1: Service d'Hématologie-Greffe de Moelle and 2: Laboratoire d'Hématologie, Hôpital Saint Louis, Paris, France

Publication date: February 1, 2001

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more