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Organ specificity of c‐kit+ lymphoid precursors in the liver, thymus, andbone marrow

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Abstract: c‐kit+Lin cells are present in various immune organs, including the liver, thymus, and bone marrow, where lymphoid, myeloid, or erythroid cells are generated. To compare their properties as lymphoid precursors, c‐kit+Lin cells purified from various organs of B6.Ly5.1 mice were injected into 6.5 Gy‐irradiated B6.Ly5.2 mice. Depending on the source of the c‐kit+ cells, the degree of entrance and expansion of lymphoid cells differed in the liver and thymus of recipient mice. c‐kit+ cells isolated from the bone marrow entered and expanded prominently in both the liver and thymus, whereas c‐kit+ cells from the thymus did not do so at all. On the other hand, c‐kit+ cells isolated from the liver and spleen showed an intermediate pattern, namely, they took a long time to enter and expand in the liver and thymus of recipient mice. All of these c‐kit+ cells had the potential to give rise to lymphoid cells, which were specific to the liver and thymus, respectively. We previously showed that progenitor cells for extrathymic T cells in the liver and those for conventional T cells in the thymus are not always supplied by the bone marrow, as shown by experiments using parabiosis. Taken together with those previous data, the present results suggest that c‐kit+Lin cells isolated from various immune organs have organ specific properties.
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Keywords: bone marrow; c‐kit+ cells; liver; organ specificity; thymus

Document Type: Research Article

Affiliations: 1: Department of Immunology and 2: First Department of Surgery, Niigata University School of Medicine, Niigata, Japan

Publication date: June 1, 2000

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