Apoptotic properties of the type 1 interferon induced family of mitochondrial membrane ISG12 proteins
– novel members of the BH3-only-like family of proteins
We will present data showing that the ISG12A variants, as well as ISG12B and ISG12C either induce apoptosis directly, or prime the cells for apoptosis by the apoptosis inducers gossypol and TNFα. In contrast 6–16 do not have the same apoptotic properties as the other members of the ISG12 family of proteins. We will also present electron microscopy data showing that these proteins are localized in the mitochondrial membrane. Thus the apoptotic properties of this ISG12 family of type 1 IFN induced proteins most likely occur in the mitochondria permeabilization process during apoptosis. This suggestion is further supported by the finding of a putative Bcl-2 homology (BH)-3 motif in the sequences of the ISG12 proteins. Collectively, these findings indicate that the ISG12 proteins are members of a novel BH3-only-like family of proteins.
Document Type: Abstract
Affiliations: 1: Molekylærbiologisk Institut, Aarhus Universitet, C. F. Møllers Alle 1130, 8000 Århus C 2: UQ Diamantina Institute for Cancer, Immunology and Metabolic Medicine, The University of Queensland, Brisbane, QLD 4072. Australia 3: Cellebiologisk afd., Anatomisk Institut, Wilhelm Meyers Alle 1234, Aarhus Universitet, 8000 Århus C
Publication date: May 1, 2008