Skip to main content
padlock icon - secure page this page is secure

Local collagen-gentamicin for prevention of sternal wound infections: the LOGIP trial

Buy Article:

$52.00 + tax (Refund Policy)

Friberg Ö. Local collagen-gentamicin for prevention of sternal wound infections: the LOGIP trial. APMIS 2007;115:1016–21.

In cardiac surgery, sternal wound infection (SWI) continues to be one of the most serious postoperative complications. Coagulase-negative staphylococci (CoNS) have become the most common causative agents of SWI. However, many CoNS species are resistant to routine intravenous antibiotic prophylaxis. 2000 cardiac surgery patients were randomised to routine prophylaxis with intravenous isoxazolyl penicillin alone (control group) or to this prophylaxis combined with application of collagen-gentamicin (260 mg gentamicin) sponges within the sternotomy before wound closure. The primary end-point was any sternal wound infection within 2 months postoperatively. The incidence of any sternal wound infection was 4.3% in the treatment group and 9.0% in the control group (relative risk=0.47; 95% confidence interval 0.33 to 0.68; P<0.001). Local gentamicin reduced the incidence of SWI caused by all major clinically important microbiological agents, including CoNS. Routine use of the described prophylaxis in all adult cardiac surgery patients could be recommended.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Propionibacterium; Sternal wound infection; antibiotic prophylaxis; infection control; mediastinitis; primary prevention; staphylococcal infection; surgical complication; surgical wound infection

Document Type: Research Article

Publication date: September 1, 2007

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more